• Gaard Science Team

CBD - A Current Perspective

Updated: Nov 17

Cannabis is one of the most intriguing plants on Earth. The flower has been utilized by civilizations as far back as 5,000 years ago - as a religious sacrament, a medicine, and also for leisure. Cannabidiol (CBD), is one of the most well-known cannabis compounds known today, second only to Tetrahydrocannabinol (THC). One of at least 113 distinct biochemicals currently known to be contained within the cannabis flower, it is a compound that's been confirmed to have a wide range of therapeutic properties and uses and is included today in many new pain, inflammation and wellness products..


CBD was first discovered in 1940 by a team lead by Roger Adams and Lord Todd. However, the breakthrough for cannabis research and pharmacology came in 1963 and 1964, when Raphael Mechoulam mapped the structure of the CBD and THC cannabinoids. He took this one step further in 1965 when he successfully isolated each from the cannabis flower. This allowed scientists to finally begin studying their mysterious biochemical properties and launch the field of cannabis medicine. But what does CBD actually do?




Source: AnalyticalCannabis


What’s So Special About CBD?

Where CBD differs from its famous sibling THC is that it has no psychoactive properties. In other words, no feeling of being “high” accompanies the therapeutic benefits that CBD can provide.


Moreover, CBD mitigates the side effects of THC like anxiety, dysphoria, panic, and paranoia, while at the same time making THC’s therapeutic activity much more significant. This is one of the reasons it has generated such buzz around the potential uses for such a compound in medicine. CBD has been researched and found to have a great deal of potential including:

· Anxiolytic

· Antiepileptic

· Antipsychotic

· Anti-Inflammatory

· Neuroprotective


The cannabis plant contains other compound that are even less known called terpenes, but which are critical in augmenting the potential of both THC and CBD. Some CBD manufacturers pay particular attention to the "entourage effect" these three can produce and make sure to create the right blend to achieve the greatest effectiveness. But what is a terpene?


Terpenes – overlooked no longer!

Just like CBD, cannabis terpenes are an understudied part of the flower’s biology. In fact they exist throughout nature, providing flavor and aroma to many fruits and flowers. From a medical perspective, they interact with major and minor cannabinoids often enhancing the overall effects and properties, while at the same time offering their own therapeutic benefits. But finding the right terpenes and the right relative dosages of CBD and terpenes can be tricky. Let’s take a look at some of the major studied uses for CBD and terpenes.


How is CBD Being Used Today?

There are more uses for CBD and other cannabinoids being discovered daily, but here are some of the more well-researched functions of this versatile biochemical.


Pain

Pain is one of the most direct and simple ways to understand something is wrong in your body. Its consequences and effects seem as varied as the number of stars in the night sky. Pain is often categorized as aching, stabbing, throbbing, steady, or pinching, but medically is divided into acute, and chronic pain.


Opiates have too often been the apparently "easy" solution when pain becomes a serious problem. But the epidemic of addiction that's ravaged America has finally led most doctors and patients to seek safer alternatives. CBD offers a healthier, and natural alternative to traditional pain treatments. Unlike THC, which also offers significant analgesic properties, CBD which binds with the many CB1 and CB2 receptors throughout the body has been found to bring significant relief for a variety of pain symptoms. A study on neuropathic pain found that CBD was the only cannabinoid that reacted with a receptor that directly related to neuropathic pain. Another more recent study found that CBD topicals could be an effective preventative and protective measure against Osteoarthritis progression.


Inflammation and Wellness

Inflammation is another way your body protects itself and alerts you something is wrong. Symptoms range from redness and pain to swelling and stiffness, and more. From sports to work to simple daily wear and tear, our bodies take a beating. Sometimes this inflammation if left untreated can turn to disease.


In studies done as far back as 2000, CBD has been found to exhibit a wide range of anti-inflammatory properties, including aiding with collagen-induced arthritis, meningitis, colitis, among many others.


Anxiety

That pounding heart, the sweaty palms, the feeling of being closed in and trapped, with thoughts racing around like a NASCAR competition. If you’ve ever felt these things on a regular basis, you know full well what it is like to live with anxiety. The Anxiety and Depression Association of America found that over 18% of the adult population in the US suffer from some sort of anxiety disorder. CBD has become a more and more frequently referenced treatment option when patients seek out alternatives to prescription medications.

A 2015 study into the effects of CBD on anxiety disorders found that it is a very effective treatment method for a wide range of disorders and conditions. A more recent CBD study found that not only is CBD effective for treating anxiety, but the actual benefit tends not to fluctuate over time, but rather stay modulated.


Today, consumers can find specially formulated sprays and tinctures that exploit CBD's anti-anxiety and calming effects. Many people have begun incorporating them into their daily routine.

What’s The Latest In CBD Science?

CBD research in recent years has expanded significantly. The U.S. National Institute of Health database lists at least 100 studies across the world involving CBD that are either recruiting subjects or in active trials. In 2018, the FDA approved the world’s first cannabinoid-derived pharmaceutical drug called Epidiolex, to treat severe and rare forms of epilepsy.

The year before, the World Health Organization presented its findings that “In humans, CBD exhibits no effects indicative of any abuse or dependence potential.” In addition, they concluded “…there is no evidence of public health related problems associated with the use of pure CBD.” This and other evidence has led to many countries shifting to a much friendlier policy towards CBD.


We're just beginning to discover the ways CBD and the rest of the cannabis plant can benefit humanity. It's truly a new frontier for medicine and one that Gaard Labs is proud to be part of. Check out Gaard's Research Vault and follow us on Facebook to keep up with the latest progress!

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